The series centers on the surreal adventures and antics of three anthropomorphic fast food items: Master Shake, a selfish, pathologically lying milkshake; Frylock, an intelligent, well-meaning box of French fries; and Meatwad, a shapeshifting, simple-minded ball of ground meat. They live together like relatives and rarely get along with their human neighbour Carl Brutananadilewski, a balding, middle-aged, sex-crazed sports fanatic. The protagonists also interact with various villains or other individuals in each episode; these interactions are often restricted to one episode, with minor characters rarely reappearing in the following episodes. Some episodes feature the protagonists interacting with celebrities, historical figures, or professional athletes.